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2-OXO ACID CARBOXY-LYASE
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DeCS
Descriptor
English
:
Pyruvate Decarboxylase
Descriptor
Spanish
:
Piruvato Descarboxilasa
Descriptor
Portuguese
:
Piruvato Descarboxilase
Synonyms
English
:
2-Oxo Acid Carboxy-Lyase
alpha-Carboxylase
alpha-Ketoacid Carboxylase
Pyruvic Decarboxylase
Tree Number:
D08.811.520.224.125.750
Definition
English
:
Catalyzes the
decarboxylation
of an alpha keto acid to an aldehyde and
carbon dioxide
.
Thiamine pyrophosphate
is an essential cofactor. In lower organisms, which ferment
glucose
to
ethanol
and
carbon dioxide
, the enzyme irreversibly decarboxylates
pyruvate
to
acetaldehyde
. EC 4.1.1.1.
History Note
English
:
91(75); was see under CARBOXY-LYASES 1975-90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22630
Unique Identifier:
D011767
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS